Massimo Delledonne Dipartimento di Biotecnologie
Università degli Studi di Verona


    Dr. Massimo Delledonne  

              Department of Biotechnology

               Personal Genomics S.R.L.


   Dipartimento di Biotecnologie

   Universita' degli Studi di Verona

   Strada le Grazie 15

   37134 Verona, Italy  
  How to reach the Department

Massimo Delledonne received his Ph.D. from Università Cattolica del S. C. in 1994.  During 1995-1998 he visited Chris Lamb at the Salk Institute for Biological Studies in California, discovering the function of nitric oxide in plant disease resistance. In 2001, he joined the University of Verona as Associate Professor of Plant Genetics (SSD Agr/07).Together with his colleague Mario Pezzotti, in January 2007 founded the Center of Functional Genomics. This center is dedicated to the development and use of the new tools that the new genomic technologies are offering to microbial, plant, animal and human biologists.

Massimo Delledonne is currently Full Professor of Genetics (SSD Bio/18). He manages a vigorous research program that emphasizes interdisciplinary approaches to understanding plant and human biology. His own expertise is in the areas of genetics, molecular biology and genomics, and collaborates with researchers in diverse fields, including bioinformatics, microbiology and plant genomics, and medicine.

He is co-founder of Personal Genomics S. R. L., a former spin-off of University of Verona established in 2011 that operates in the field of human genomics and personalized medicine, now part of the SOL group.

Massimo Delledonne has been supported by the EMBO Young Investigator Program
Member of the International Cancer Genome Consortium
Member of the Understand Your Genome program

Understand Your Genome (UYG) is part of a movement promoted by Illumina towards a better understanding of our DNA and its implications for healthcare. I've sequenced myself in 2011, and I've joined this program in 2012. As geneticist, I'm now fully involved in educating and motivating the medical community to precision medicine: coupling established clinical–pathological indexes with state-of-the-art molecular profiling to create diagnostic, prognostic, and therapeutic strategies precisely tailored to each patient's requirements.

October 2017 Congo expedition (short movie)
Short movie produced by Simone Pecorari (UQ film) for the Oxford Nanopore Day - Italy
February 2017 Congo expedition: the blog
The blog of the Congo expedition, sequencing wild species with the MinION. Stay tuned for the movie
November 2016 Genetica ed epigenetica: la memoria del DNA

October 2016: La ricerca genetica ed il miglioramento della qualità della vita

Congresso Nazionale ANDAF
January 2016: Geni e genomi: la bellezza nascosta del nostro DNA

SAP Executive Summit 2016
May 2015: Tanzania expedition  Short movie of the expedition to Rungwe vulcano, shown at London Calling (Oxford Nanopore) event
May 2015: Tanzania expedition PROMO
(link to the promo of the expedition to Rungwe vulcano where we will sequence frogs into the jungle)
April 2015: Revealed my genome at SAS Forum (in italian)
November 2014: Why we should know our genome (in italian, soon with english subts)

November 2014: Member of UYG Key Opinion Leaders
April 2014:  Selected to participate to the first Oxford Nanopore MinION Access Program
February 2014:  Revealed my genome at TEDx Verona (in italian): My Beautiful Genome


Massimo Delledonne is among the Top Italian Scientists (VIA Academy)

Top 10 publications from the Nitric Oxide lab:

  • Delledonne M., Xia Y., Dixon R. and Lamb C. (1998). Nitric oxide functions as a signal in plant disease resistance. Nature 394:585-558
  • Solomon M., Belenghi B., Delledonne M., Levine A. (1999). The involvement of cysteine proteases and protease inhibitor genes  in the regulation of programmed cell death in plants. Plant Cell 11:431-443
  • Delledonne M., Zeier J., Marocco A., Lamb C. (2001) . Signal interactions between nitric oxide and reactive oxygen intermediates in the plant hypersensitive disease resistance response. Proc. Natl. Acad. Sci. USA 98:13454-13459
  • Zeier J., Delledonne M., Severi E., Sonoda M., Lamb C. (2004). Genetic elucidation of nitric oxide signaling in incompatible plant-pathogen interactions. Plant Physiol. 136:2875-2886
  • Perazzolli M., Dominici P., Romero-Puertas M., Zago E., Zeier J., Sonoda M., Lamb C., Delledonne M. (2004) Arabidopsis non-symbiotic hemoglobin AHb1 modulates nitric oxide bioactivity. Plant Cell 16:2785-2794
  • Boccara M., Mills C., Zeier J., Anzi C., Lamb C., Poole R., Delledonne M. (2005)  Flavohaemoglobin HmpX from Erwinia chrysanthemi confers nitrosative stress tolerance and affects the plant hypersensitive reaction by intercepting nitric oxide produced by the host . Plant J. 43:226-237 
  • Zaninotto F., La Camera S., Polverari A., Delledonne M. (2006) Cross talk between reactive nitrogen and oxygen species during the hypersensitive response. Plant Physiol. 141: 379-383
  • Zago E., Morsa S., Dat J.F., Alard P., Ferrarini A., Inzè D., Delledonne M., Van Breusegem F. (2006) Nitric oxide- and hydrogen peroxide-responsive gene regulation during cell death induction in tobacco. Plant Physiol. 141: 404-411
  • Romero-Puertas M.C., Laxa M., Mattè A., Zaninotto F., Finkemeier I., Jones A.M.E.,  Perazzolli M., Vandelle E., Dietz K.J., Delledonne M. (2007) S-nitrosylation of peroxiredoxin II E promotes peroxynitrite-mediated tyrosine nitration. Plant Cell 19: 4120-4130
  • Gaupels F., Spiazzi-Vandelle E., Yang D., Delledonne M. (2011). Detection of peroxynitrite accumulation in Arabidopsis thaliana during the hypersensitive defense response. Nitric Oxide 25:222-228

Top 10 publications from the Functional Genomics lab:

  • The French–Italian Public Consortium for Grapevine Genome Characterization. (2007). The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla. Nature 449: 463-467
  • Denoeud F., Aury JM., Da Silva C., Noel B., Rogier O., Delledonne M., Morgante M., Valle G.,  Wincker P., Scarpelli C., Jaillon O., Artiguenave F. (2008) Annotating genomes with massive-scale RNA-sequencing. Genome Biology 9: R175
  • Ventura M., Turroni F., Zomer A., Foroni E., Giubellini V., Bottacini F., Canchaya C., Claesson M.J., He F., Mantzourani M., Mulas L., Ferrarini A., Gao B., Delledonne M., Henrissat B., Coutinho P., Oggioni M., Gupta R.S., Zhang Z., Beighton D., Fitzgerald G.F., O’Toole P.W., van Sinderen D. (2009). The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity. PLoS Genetics 5(12): e1000785
  • The International Cancer Genome Consortium. (2010). International network of cancer genome projects. Nature 464:993-998
  • Turroni F., Bottacini F., Foroni E., Mulder I., Kim J.H., Zomer A., Garcia B.S., Bidossi A., Ferrarini A., Giubellini V., Delledonne M., Henrissat B., Coutinho P., Oggioni M., Fitzgerald G.F., Mills D., Margolles A., Kelly D., van Sinderen D., Ventura M. (2010). Genome analysis of Bifidobacterium bifidum PRL2010 reveals metabolic pathways for host-derived glycan foraging. Proc Natl Acad Sci. USA 107: 19514-19519
  • Mele C., Iatropoulos P., Donadelli R., Calabria A., Maranta R., Cassis P., Buelli S., Tomasoni S., Piras R., Krendel M., Bettoni S., Morigi M., Delledonne M., Pecoraro C., Abbate I., Capobianchi M.R., Hildebrandt F., Otto E., Schaefer F., Macciardi F., Ozaltin F., Emre S., Ibsirlioglu T., Benigni A., Remuzzi G. and Noris M. (2011). MYO1E mutations and childhood familial focal segmental glomerulosclerosis. New Engl. J. Med. 365 : 295-306  
  • Dal Santo S., Tornielli G., Zenoni S., Fasoli M., Farina L., Anesi A., Guzzo F., Delledonne M., Pezzotti M. (2013). The plasticity of the grapevine berry transcriptome. Genome Biol. 14: R54
  • Da Silva C., Zamperin G., Ferrarini A., Minio A., Dal Molin A., Venturini L., Buson G., TononiP.,  Avanzato C., Zago E., Boido E., DellacassaE., Gaggero C., Pezzotti M., Carrau F., Delledonne M. (2013). The high polyphenol content of Vitis vinifera cv. Tannat berries is conferred mostly by genes that are not shared with the reference genome. Plant Cell 25:4777-4788
  • Venturini L, Delledonne M. (2015) Symbiotic plant-fungi interactions stripped down to the root. Nature Genet. 2015 47: 309-310
  • Chin C.S., Peluso P., Sedlazeck F.J., Nattestad M., Concepcion G.T., Clum A., Dunn C., O'Malley R., Figueroa-Balderas R., Morales-Cruz A., Cramer G.R., Delledonne M., Luo C., Ecker J.R., Cantu D., Rank D.R., Schatz M.C. (2016). Phased diploid genome assembly with single-molecule real-time sequencing. Nat Methods. 13: 1050-1054.

In press:


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For more information, please visit the Delledonne lab homepage

Last update October 21st, 2017